Located in upper northwest Washington between 16th Street and Georgia Avenue, the 113-acre Walter Reed Campus is one of the most famous military hospitals in the United States. It is slated for closure under the Base Realignment and Closure Act. The historic hospital opened its doors in May of 1909 to ten patients and fourteen years later Gen. John J. Pershing signed the order creating the Army Medical Center. In 1951 the complex of 100 rose-brick Georgian style buildings became known as the Walter Reed Army Medical Center. An application has been filed to designate the entire campus as an historic district, with listing on the National Register.

In January 2010 the C100 Trustees approved a resolution supporting the proposed landmark designation of the Walter Reed Historic District and authorizing the Historic Preservation Subcommittee to take appropriate action in support of this designation.  Walter Reed closed in September 2011.  Part of its campus (67.5 acres) is slated to go to the District of Columbia; the remainder (45.5 acres) will be transferred to the Department of State for potential embassy use.  Committee members have participated in meetings relating to the Section 106 review process required by the Advisory Council on Historic Preservation for the DC portion of the property.  A formal Programmatic Agreement is being drafted by the Army, the Advisory Council and the DC Office of Historic Preservation.  It is expected to be released for public comment this fall.  It is expected that a separate Section 106 process will be initiated by the Department of State relating to plans for developing its portion of the site, and C 100 intends to participate in that process as well.